Overview of Published Clinical Reports

 [1] T.H. Crook. Treatment of Age-Related Cognitive Decline: Effects of Phosphatidylserine, in Anti-Aging Medical Therapeutics, Vol II, edited by R.M. Klatz, Health Quest Publications, Chicago, 1998, 20-29.

[2] Asymmetry of brain microsomal membranes. L. Freysz, C. Dreyfus, C. Vincendon, In: L. Horrocks, ed. Phospholipids in the nervous system, v. 1. New York: Raven Press, 1982, 37-47.

[3] G. Calderoni, F. Aporti, F. Bellini, A.C. Sonetti, R. Rubini, S. Telato, C. Xu, A. Canotti, G. Toffano. Phospholipids as pharmacological tools in the aging brain. In: L.A. Horrocks, J.N. Kanfer, G. Porcellati (eds). Phospholipids in the nervous system, vol 2, Physiological roles. Raven Press, New York, 1985, 11-19.

[4] K. Kaibuchi, Y. Takay, Y. Nishizuka. Cooperative roles of various membrane phospholipids in the activation of calcium-activated, phospholipid-dependent protein kinase. J. Biol. Chem. 1981, 256, 7146-7149.

[5] J. Raese, R.L. Patrick, J.D. Barchas. Phospholipid-induced activation of tyrosine hydroxylase from rat brain striatal synaptosomes. Biochem Pharmacol 1976, 25, 2245-2250.

[6] S. Tsakiris, G. Deliconstantinos. Influence of phosphatidylserine on (Na+/K+)-stimulated ATPase and acetylcholinesterase activities of dog brain synaptosomal plasma membranes. Biochem J. 1984, 220, 301-307.

[7] S.C. Specht, J.D. Robinson. Stimulation of the (Na+/K+)-dependent adenosine triphosphatase by amino acids and phosphatidylserine: chelation of trace metal inhibitors. Arch Biochem Biophys 1973, 154, 314-323.

[8] M.G. Nunzi, F. Milan, D. Guidolin, G. Toffano. Dendritic spine loss in hippocampus of aged rats. Effect of brain Phosphatidylserine administration. Neurobiol Aging 1987, 8, 501-510.

[9] M.G. Vannucchi, G. Pepeu. Effect of Phosphatidylserine on Acetylcholine Release and Content in Cortical Slices From Aging Rats. Neurobiol Aging 1987, 8(5), 403-407.

[10] M.G. Vannucchi, F. Casamenti, G. Pepeu. Decrease of acetylcholine release from cortical slices in aged rats: investigations into its reversal by Phosphatidylserine. J. Neurochem 1990, 55, 819-25.

[11] G. Pepeu, L. Giovanelli, M.G. Giovannini, F. Pedata. Effects of Phosphatidylserine on cortical acetylcholine release and calcium uptake in adult and aging rats. In Phospholipid research and the nervous system. Biochemical and molecular pharmacology. L.A. Horrocks, L. Freysz, G. Toffano (Eds), Liviana Press, Padova, 1986, 265-271.

[12] M.G. Vannucchi, F. Casamenti, G. Pepeu. Decrease of Acetylcholine release from cortical slices in aged rats: investigations into its reversal by Phosphatidylserine. J. Neurochem. 1990, 55, 819-825.

[13] F. Casamenti. P. Mantovani, L. Amaducci, G. Pepeu. Effect of phosphatidylserine on acetylcholine output from the cerebral cortex of the rat. J. Neurochem 1979, 32, 529-533.

[14] F. Casamenti, C. Scali, G. Pepeu. Phosphatidylserine reverses the age-dependent decrease in cortical acetylcholine release: a microdialysis study, Eur. J. Pharmacol 1991, 194, 11-16.

[15] F. Pedata, L. Giovannelli, G. Spignoli, M.G. Giovannini, G. Pepeu. Phosphatidylserine increases acetylcholine release from cortical slices in aged rats. Neurobiol Aging 1985, 6, 337-339.

[16] S. Mazzari, A. Battistella. Phosphatidylserine effects on dopamine release from striatum synaptosomes. In: Multidisciplinary Approach to Brain Development. C. Benedetta, R. Balazs, G. Gombos, G. Porcellani (Eds.). Elsevier/North Holland, Amsterdam, 1980, 569-570.

[17] S.A. Cohen, W.E. Müller. Age-Related alterations of NMDA-receptor properties in the mouse forebrain: partial restoration by chronic phosphatidylserine treatment. Brain Research 1992, 584, 174-180.

[18] A. Zanotti, L. Balzelli, G. Toffano. Chronic phosphatidylserine treatment improves special memory and passive avoidance in aged rats. Psychpharmacology 1989, 99, 316-321.

[19] A. Zanotti, F. Aporti, R. Rubini, G. Toffano. Learning and memory deficits in rat during aging: effect of phosphatidylserine treatment. In: Modulation of central and peripheral transmitter function. G. Biggio, P.F. Spano, G. Toffano, G.L. Gessa (Eds), Liviana Press, Padova, 1986, 323-330.

[20] F. Drago, G. Toffano, L. Catalano Rossi Danielli, G. Continella, U. Scapagnini. Phosphatidylserine facilitates learning and memory process in aged rats. In: Aging of the brain, D. Sanual et al (Eds), Raven Press, New York, 1983, 309-316.

[21] M. Furushiro, S. Suzuki et al. Effects of oral administration of soybean lecithin transphosphtidylated PS on impaired learning of passive avoidance in mice. Jpn. J. Phamacol. 1997, 75, 447-450.

[22] M. Sakai, H. Yamatoya, S. Kudo. Pharmacological effects of Phosphatidylserine synthesized from soybean lecithin on brain functions in rodents. Nutr. Sci. Vitaminol. 1996, 42, 47-54.

 

[23] A. Zanotti, F. Aporti, G. Toffano, L. Balzelli. Effects of phosphatidylserine on avoidance relearning in rats. Pharmacol Res Comm 1984, 16, 485-493.

[24] F. Drago, P.L. Canonico, U. Scapagnini. Behavioral effects of PS in the aged rats. Neurobiol. Aging 1981, 2, 209-213

[25] J. Corwin, R.L. Dean, R.T. Bartus, J. Rotrosen, D.L. Watkins. Behavioral effects of Phosphatidylserine in aged Fischer 344 rats: amelioration of passive avoidance deficits without changes in psicomotor task performance. Neurobiol Aging 1985, 6, 11-15.

[26] A. Blokland, W. Honig, F. Brouns, J. Jolles. Cognition-enhancing properties of subchronic phosphatidylserine (PS) treatment in middle-aged rats: comparison of bovine cortex with egg PS and soybean PS. Nutrition 1999, 15, 778-783.

[27] R.G.M. Morris. Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci Methods 1984, 11, 47-60.

[28] P.J. Delwaide, A.M. Gyselynck-Mambourg, A. Hurlet, M. Ylieff. Double-blind randomized controlled study of Phosphatidylserine in senile demented patients. Acta Neurol Scand 1986, 73, 136-140.

[29] G. Ransmayr, S. Ploerer, F. Gerstenbrand, G. Bauer. Double-blind placebo-controlled trial of phosphatidylserine in elderly patients with arteriosclerotic encephalopaty. Clin J Trials 1987,24, 62-72.

[30] P. Caffarra, V. Santamaria. The Effects of Phosphatidylserine in patients with mild cognitive decline. Clin. Trials J. 1987, 24, 109-114.

[31] L. Allegro, V. Favaretto, G. Ziliotto. Oral Phosphatidylserine in elderly patients with cognitive deterioration. An open study. Clin. Trials J. 1987, 24, 104-108.

[32] G. Palmieri, R. Palmieri, M.R. Inzoll, A.M. Agrati, A: Vargiu. Double-blind controlled trial of phosphatidylserine in patients with senile mental deterioration. Clin. Trials. J. 1987, 24, 73-83.

[33] J.C. Villardita, S. Grioli, G. Salmeri, F. Nicoletti, G. Pennisi. Multicenter clinical trial of brain phosphatidylserine in elderly patiens with intellectual deterioration, Clin. Trials J. 1987, 24, 84-93.

[34] E. Sinforiani, C. Agostinis, P. Merlo, S. Gualtieri, M. Mauri, A. Mancuso, Cognitive Decline in ageing brain. Therapeutic Approach with Phosphatidylserine. Clin. Trials J. 1987, 24, 115-124.

[35] L. Amaducci and the SMID group. Phosphatidylserine in the treatment of Alzheimer disease: results of a multicenter study. Psicopharmcol Bull 1988, 24, 130-134.

 

[36] T.H. Crook, J. Tinklenberg, J. Yesavage, W. Petrie, M.G. Nunzi, D.C. Massari. Effects of phosphatidylserine in age-associated memory impairment. Neurol. 1991, 41, 644-649

[37] T.H. Crook, W. Petrie, C. Wells, D.C. Massari. Effects of Phosphatidylserine in Alzheimer’s Disease. Psicopharmcol Bull 1992, 28, 61-66.

[38] R.R. Engel, W. Satzger, W. Günther, N. Kathmann, D. Bove, S. Gerke, U. Münch, H. Hippius. Double-Blind cross-over study of phosphatidylserine vs. placebo in patients with early dementia of the Alzheimer type. Eur Neuropsychopharmacol 1992, 2, 149-155.

[39] T. Cenacchi, T. Bertoldin, C. Farina, M.G. Fiori, G. Crepaldi et al Cognitive decline in the elderly: A double-blind, placebo-controlled multicenter study on the efficacy of phosphatidylserine administration. Aging Clin. Exp. Res. 1993, 5, 123-133.

[40] J. Gindin, M. Novikov, D. Dedar, A. Walter-Ginzburg, S. Naor, S. Levi. The Effect of plant phosphatidylserine of age-associated memory impairment and mood in the functioning elderly. The Geriatric Institute for Education and Research, and Department of Geriatrics, Kaplan Hospital, Rehovot, Israel 1995.

[41] S. Schreiber, O. Kampf-Sherf, M. Gorfine, D. Kelly, Y. Oppenheim, B. Lerer. An open trial of plant-source derived Phosphatidylserine for the treatment of age-related cognitive decline. Isr. J. Psychiatry Relat. Sci. 2000, 37, 302-307.

[42] M. Sakai, H. Yamatoya, S. Kudo. Pharmacological effects of Phosphatidylserine synthesized from soybean lecithin on brain functions in rodents. Nutr. Sci. Vitaminol. 1996, 42, 47-54.

[43] M. Furushiro, S. Suzuki et al. Effects of oral administration of soybean lecithin transphosphtidylated PS on impaired learning of passive avoidance in mice. Jpn. J. Phamacol. 1997, 75, 447-450.

[44] A. Blokland, W. Honig, F. Brouns, J. Jolles. Cognition-Enhancing Properties of Subchronic Phosphatidylserine (PS) Treatment in Middle-Aged Rats: Comparison of Bovine Cortex PS With Egg PS and Soybean PS. Nutrition 1999, 15, 778-783.

[45] T.D. Fahey, M.S. Pearl . The Hormonal and Perceptive Effects of Phosphatidylserine Administration During Two Weeks of Weight Training-Induced Over-Training, , Biol. Sport. 1998, 15, 135-144.

[46] S.W. Souci, E. Fachmann, H. Kraut. Food Composition and Nutrition Tables. Medpharm Scientific Publishers Stuttgart 2000.

[47] ZMP (Zentrale Markt- und Preisberichtsstelle für Erzeugnisse der Land-, Forst- und Ernährungswirtschaft GmbH Bonn): Marktbilanz 2001.

[48] M. Hamm. Ernährungswissenschaftliche Stellungnahme zur Veränderung der nutritiven Versorgung mit Phosphatidylserin (PS), 2002.

PS + PA = Optimal Brain Power

Did you know that Lipogen PS Plus contains PS (phosphatidylserine) and a supporting phospholipid called PA (phosphatidic acid)? This combination of nutrients can help energize your mood and memory.

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US Food and Drug Administration Says..
The US Food and Drug Administration says Lipogen PS is safe for food fortification. PS is the ONLY natural health supplement that has a "qualified health claim for both - COGNITION and MEMORY"!

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